Cyclotriazadisulfonamide hydrochloride ( Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) )

产品货号. M28215 CAS No. 392287-03-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Cyclotriazadisulfonamide hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Cyclotriazadisulfonamide 盐酸盐是一种 CD4 靶向 HIV 进入的选择性抑制剂，并以信号肽依赖性方式抑制人 CD4 共翻译易位到 ER 腔中。
产品描述

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.(In Vitro):Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4.Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far.
体外实验

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体内实验

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同义词

Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
通路

Microbiology/Virology
靶点

HIV
受体

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研究领域

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适应症

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CAS Number

392287-03-5
分子量

618.25
分子式

C31H40ClN3O4S2
纯度

>98% (HPLC)
溶解度

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SMILES

CC1=CC=C(S(=O)(N(CCCN(CC2=CC=CC=C2)CCCN(S(C3=CC=C(C=C3)C)(=O)=O)C4)CC4=C)=O)C=C1.Cl
化学全称

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1.Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29.

计算器

产品手册

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